Biochemical studies of inherited diseases related to abnormal cholesterol metabolism. I. High-performance liquid chromatographic analysis of bile alcohol glucuronides in cerebrotendinous xanthomatosis.

Abstract	We developed a rapid and simple quantitative method for measuring bile alcohol glucuronides in serum involving high-performance liquid chromatography without group separation and hydrolysis. The assay of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol 3-glucuronide, the major bile alcohol component in serum from cerebrotendinous xanthomatosis patients, with the present method was useful for the diagnosis of cerebrotendinous xanthomatosis.
Authors	A Ohshima, T Kuramoto, T Hoshita
Journal	Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 17 Issue 5 Pg. 721-3 (May 1994) ISSN: 0918-6158 [Print] Japan
PMID	7920441 (Publication Type: Journal Article)
Chemical References	Cholestanols Glucuronates Indicators and Reagents cholestane-3,7,12,26-tetrol Cholesterol
Topics	Cholestanols (blood) Cholesterol (metabolism) Chromatography, High Pressure Liquid Female Glucuronates (blood) Humans Indicators and Reagents Lipid Metabolism, Inborn Errors (blood, diagnosis, metabolism) Male Xanthomatosis (blood, diagnosis)

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