Cu-ATSM, an intracellular-accessible superoxide dismutase (SOD)-like copper complex: evaluation in an ischemia-reperfusion injury model.

Abstract

We have reported a stable superoxide dismutase (SOD)-like copper complex, Cu-ATSM, which shows high membrane permeability and distribution to the brain or heart. In this study, we evaluated the protective effects of Cu-ATSM on superoxide-mediated tissue damage caused by ischemia-reperfusion using an isolated perfused rat heart model. Lipid peroxidation levels in the Cu-ATSM treated group were lower than those in the non-treated group. Furthermore, released creatine phosphokinase into the perfusate, a marker of tissue damage, was reduced by Cu-ATSM treatment. These results indicated the possibility of Cu-ATSM being an effective SOD-like drug for the treatment of superoxide-mediated damage, such as ischemia-reperfusion injury.

• Authors: K Wada, Y Fujibayashi, N Tajima, A Yokoyama
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 17 Issue 5 Pg. 701-4 (May 1994) ISSN: 0918-6158 [Print] Japan
• PMID: 7920437 (Publication Type: Journal Article)

Chemical References

• Coordination Complexes
• Free Radical Scavengers
• Organometallic Compounds
• Thiobarbituric Acid Reactive Substances
• Thiosemicarbazones
• copper (II) diacetyl-di(N(4)-methylthiosemicarbazone)
• Superoxides
• Superoxide Dismutase
• Creatine Kinase

Topics

• Animals
• Coordination Complexes
• Coronary Circulation (drug effects)
• Creatine Kinase (metabolism)
• Free Radical Scavengers
• Hemodynamics (drug effects)
• In Vitro Techniques
• Male
• Myocardial Ischemia (drug therapy, physiopathology)
• Myocardial Reperfusion Injury (drug therapy, physiopathology)
• Myocardium (enzymology)
• Organometallic Compounds (pharmacology)
• Rats
• Rats, Wistar
• Superoxide Dismutase (pharmacology)
• Superoxides (toxicity)
• Thiobarbituric Acid Reactive Substances (metabolism)
• Thiosemicarbazones (pharmacology)