Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.

Abstract

To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin F (17) and cucurbitacin F (18) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Further, compounds 14 and 17 exhibited remarkable anti-tumor-promotion effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

• Authors: T Konoshima, M Takasaki, T Tatsumoto, M Kozuka, R Kasai, O Tanaka, R L Nie, H Tokuda, H Nishino, A Iwashima
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 17 Issue 5 Pg. 668-71 (May 1994) ISSN: 0918-6158 [Print] Japan
• PMID: 7920430 (Publication Type: Journal Article)

Chemical References

• Anticarcinogenic Agents
• Antineoplastic Agents, Phytogenic
• Triterpenes
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Anticarcinogenic Agents (pharmacology)
• Antineoplastic Agents, Phytogenic (pharmacology)
• Carbohydrate Sequence
• Drug Screening Assays, Antitumor
• Female
• Herpesvirus 4, Human (drug effects)
• Mice
• Mice, Inbred ICR
• Molecular Sequence Data
• Papilloma (microbiology, prevention & control)
• Plants, Medicinal (chemistry)
• Skin Neoplasms (chemically induced, prevention & control)
• Tetradecanoylphorbol Acetate (pharmacology)
• Triterpenes (chemistry, pharmacology, therapeutic use)
• Virus Activation (drug effects)