Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.

Abstract

Acute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.

• Authors: M N Narayanan, G R Morgenstern, J C Chang, C J Harrison, M Ranson, J H Scarffe
• Journal: British journal of haematology (Br J Haematol) Vol. 86 Issue 4 Pg. 867-9 (Apr 1994) ISSN: 0007-1048 [Print] England
• PMID: 7918085 (Publication Type: Journal Article)

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Chromosomes, Human, Pair 11
• Chromosomes, Human, Pair 4
• Female
• Follow-Up Studies
• Hodgkin Disease (drug therapy)
• Humans
• Male
• Neoplasms, Second Primary (chemically induced, genetics, therapy)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (chemically induced, genetics, therapy)
• Prognosis
• Translocation, Genetic