Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas.

Abstract

Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (X2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.

• Authors: H Suzui, J A Takahashi, M Fukumoto, N Hashimoto, N Itoh, M Hatanaka, H Kikuchi
• Journal: Neuroscience letters (Neurosci Lett) Vol. 171 Issue 1-2 Pg. 192-6 (Apr 25 1994) ISSN: 0304-3940 [Print] Ireland
• PMID: 7916136 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• Nuclear Proteins
• Proliferating Cell Nuclear Antigen
• RNA, Messenger
• Receptors, Fibroblast Growth Factor
• S100 Proteins
• Fibroblast Growth Factor 2

Topics

• Adenoma (immunology, metabolism)
• Adult
• Aged
• Antigens, Neoplasm (immunology, metabolism)
• Base Sequence
• Female
• Fibroblast Growth Factor 2 (biosynthesis, immunology, metabolism)
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Molecular Sequence Data
• Nuclear Proteins (immunology, metabolism)
• Pituitary Neoplasms (immunology, metabolism)
• Polymerase Chain Reaction
• Proliferating Cell Nuclear Antigen
• RNA, Messenger (biosynthesis)
• Receptors, Fibroblast Growth Factor (biosynthesis, immunology, metabolism)
• S100 Proteins (immunology, metabolism)