[Adverse reactions and complications of splenic perfusions: intensive therapy, prevention].

Abstract

The authors analysed the complications and side reactions in extracorporeal connection with a donor xenospleen (ECCDS) and infusion of a xenosplenoperfusate in 205 patients with surgical purulent infection. In 127 patients ECCDS was conducted during traditional premedication (atropine 4 trimeperidine hydrochloride injected into a muscle 30-40 minutes before the procedure), in which case complications like anaphylactic shock, laryngo- and bronchospasm, Lyeil's syndrome, and angioneurotic edema occurred. ECCDS and infusion of a xenosplenoperfusate in 78 patients who received multicomponent premedication had practically no complications. Experience showed that multicomponent premedication including a complex of antihistaminic agents (diphenylhydramine hydrochloride++pipolphen+suprastin) and corticosteroids is a measure of reliable prevention of anaphylactic reactions both in primary and repeated xenosplenoperfusions. In severe endotoxicosis, immunocorrection by xenosplenoperfusion is most effective and safe (particularly in repeated procedures) when combined with preliminary efferent detoxification (hemosorption, exchange plasmapheresis) and multicomponent premedication.

• Authors: V K Gostishchev, N M Fedorovskiĭ
• Journal: Khirurgiia (Khirurgiia (Mosk)) Issue 5 Pg. 55-7 (May 1994) ISSN: 0023-1207 [Print] Russia (Federation)
• Vernacular Title: Reaktsii i oslozhneniia pri ksenosplenoperfuziiakh; intensivnaia terapiia, profilaktika.
• PMID: 7914554 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Histamine H1 Antagonists

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Anaphylaxis (etiology, prevention & control)
• Angioedema (etiology, prevention & control)
• Animals
• Bronchial Spasm (etiology, prevention & control)
• Chemotherapy, Cancer, Regional Perfusion (adverse effects, methods)
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Injections, Intramuscular
• Laryngismus (etiology, prevention & control)
• Premedication
• Spleen (cytology)
• Stevens-Johnson Syndrome (etiology, prevention & control)
• Surgical Wound Infection (therapy)
• Swine