[Nootropic drugs potentiate nerve cell responses evoked by NMDA-glutamate receptor activation].

Abstract

The nootropic drugs--nootropil, aethimizol, diethylaminoethanol, and ambocarb diminished of amnesia of active avoidance habit evoked by maximal electroconvulsive shock in the rats. At the same time tested nootropic drugs potentiated the frog spinal motoneurons responses mediated by NMDA, but not non NMDA glutamate receptors activation. It was discussed the role of NMDA-potentiating nootropic drugs action in their anti-amnestic action.

• Authors: I I Abramets, P V Andreev, I V Komissarov, I M Samoĭlovich, A V Titievskiĭ
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 115 Issue 1 Pg. 51-3 (Jan 1993) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Nootropy potentsiruiut otvety nervnykh kletok, vyzyvaemye aktivatsieĭ NMDA-glutamatnykh retseptorov.
• PMID: 7914439 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Glutamates
• Neurotransmitter Agents
• Psychotropic Drugs
• Receptors, Glutamate
• Receptors, N-Methyl-D-Aspartate
• Aspartic Acid
• Glutamic Acid

Topics

• Amnesia (drug therapy)
• Animals
• Aspartic Acid (pharmacology)
• Electroshock
• Glutamates (pharmacology)
• Glutamic Acid
• Membrane Potentials (drug effects)
• Motor Neurons (drug effects)
• Neurotransmitter Agents (pharmacology)
• Psychotropic Drugs (pharmacology)
• Ranidae
• Rats
• Receptors, Glutamate (drug effects)
• Receptors, N-Methyl-D-Aspartate (drug effects)
• Spinal Cord (cytology, drug effects)