[The pharmacodynamics of proxodolol when administered once and in a course of doses to patients with stenocardia of effort].

Abstract

The effects of placebo and proxodolol, a new hybrid (beta-, alpha-) adrenoblocking agent, on exercise tolerance, hemodynamics and the conduction system were compared in 28 patients with coronary heart disease, Functional Class II-III exercise-induced angina pectoris at rest and during bicycle ergometric exercise test. Proxodolol was shown to exert a significant dose-dependent antianginal effect without producing any negative effect on atrioventricular and intraventricular conduction.

• Authors: I N Petrov, A S Rumiantsev, M V Smirnov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1994 May-Jun Vol. 57 Issue 3 Pg. 54-7 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Farmakodinamika proksodolola pri odnokratnom i kursovom naznachenii bol'nym stenokardieĭ napriazheniia.
• PMID: 7914123 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Adrenergic beta-Antagonists
• Oxadiazoles
• proxodolol

Topics

• Adrenergic alpha-Antagonists (administration & dosage, pharmacology)
• Adrenergic beta-Antagonists (administration & dosage, pharmacology)
• Angina Pectoris (drug therapy, physiopathology)
• Chronic Disease
• Dose-Response Relationship, Drug
• Drug Evaluation
• Exercise Test (drug effects)
• Female
• Hemodynamics (drug effects)
• Humans
• Male
• Middle Aged
• Oxadiazoles (administration & dosage, pharmacology)
• Physical Exertion (drug effects)