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Apolipoprotein-D polymorphism: a genetic marker for obesity and hyperinsulinemia.

Abstract
Obesity frequently clusters with hypertension, hyperlipidemia, non-insulin-dependent diabetes mellitus, and ischemic heart disease with hyperinsulinemia as syndrome X. Although central obesity has been recognized to have a strong genetic component, few candidate genes have been studied in this disorder. After a recently described association between the apolipoprotein-D (Apo-D) gene polymorphism and non-insulin-dependent diabetes mellitus by our group, we have now looked at a TaqI polymorphism of the Apo-D gene in two other components of syndrome X, namely obesity and hyperinsulinemia. Apo-D genotype differences were found between obese subjects (n = 57) and slim controls (n = 57; P = 0.006). Furthermore, in the obese group an association was found between the Apo-D genotype and fasting insulin (P < 0.001). Preliminary evidence, therefore, suggests that the TaqI Apo-D polymorphism can be used as a genetic marker for obesity and several components of syndrome X.
AuthorsS Vijayaraghavan, G A Hitman, P G Kopelman
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 79 Issue 2 Pg. 568-70 (Aug 1994) ISSN: 0021-972X [Print] United States
PMID7913935 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Apolipoproteins
  • Apolipoproteins D
  • Genetic Markers
  • Insulin
  • Deoxyribonucleases, Type II Site-Specific
  • TCGA-specific type II deoxyribonucleases
Topics
  • Adult
  • Apolipoproteins (genetics)
  • Apolipoproteins D
  • Body Mass Index
  • Deoxyribonucleases, Type II Site-Specific
  • Female
  • Genetic Markers
  • Heterozygote
  • Homozygote
  • Humans
  • Insulin (blood)
  • Male
  • Microvascular Angina (genetics)
  • Middle Aged
  • Obesity (genetics)
  • Polymorphism, Restriction Fragment Length

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