Alcohol and acetaldehyde dehydrogenase gene polymorphism and alcoholism.

Abstract

Inherited variations in alcohol and aldehyde dehydrogenases, the principal enzymes of ethanol metabolism, have been implicated in determining susceptibility to alcoholism and alcohol-related organ damage. An association between an RFLP for the alcohol dehydrogenase-2 (ADH2) gene and alcohol-induced liver damage was demonstrated in a Caucasian population. Genotyping studies revealed an increase in the ADH3(2) allele in patients with alcohol-induced cirrhosis. PCR studies of the ALDH5 gene have demonstrated diverse polymorphism within a short segment of its coding region, with marked inter-racial variation in allele frequencies. In addition, the Caucasian alcohol-induced flushing reaction has been characterised and its relationship with phenotypic polymorphism of ALDH1 examined.

• Authors: D I Sherman, R J Ward, A Yoshida, T J Peters
• Journal: EXS (EXS) Vol. 71 Pg. 291-300 ( 1994) ISSN: 1023-294X [Print] Switzerland
• PMID: 7913353 (Publication Type: Journal Article)

Chemical References

• Isoenzymes
• Alcohol Dehydrogenase
• Aldehyde Oxidoreductases
• aldehyde dehydrogenase (NAD(P)+)

Topics

• Alcohol Dehydrogenase (biosynthesis, genetics)
• Alcoholism (enzymology, genetics)
• Aldehyde Oxidoreductases (biosynthesis, genetics)
• Alleles
• Amino Acid Sequence
• Base Sequence
• Gene Frequency
• Genetic Variation
• Genotype
• Humans
• Isoenzymes (biosynthesis, genetics)
• Liver Diseases, Alcoholic (enzymology)
• Point Mutation
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length
• White People (genetics)