2-Thiazolylethylamine, a selective histamine H1 agonist, decreases seizure susceptibility in mice.

Abstract	The effects of intracerebroventricular (ICV) administration of histamine and its selective agonists on electrically and pentylenetetrazole-induced convulsions in mice were studied. The ICV administration of histamine decreased seizure susceptibility on electrically and pentylenetetrazole-induced convulsions significantly and dose-dependently. The inhibitory effects of histamine were well antagonized by centrally acting histamine H1 antagonists such as pyrilamine (or mepyramine) and ketotifen, but not by a peripherally acting histamine H1 antagonist, astemizole, or a centrally acting H2 antagonist, zolantidine. The ICV administration of 2-thiazolylethylamine, a selective histamine H1 agonist, also decreased seizure susceptibility, which could be antagonized by centrally acting histamine H1 antagonists, whereas dimaprit, a selective histamine H2 agonist, did not affect seizure susceptibility. These findings strengthened the idea that the central histaminergic neuron system plays an inhibitory role in convulsions.
Authors	H Yokoyama, K Onodera, K Iinuma, T Watanabe
Journal	Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 47 Issue 3 Pg. 503-7 (Mar 1994) ISSN: 0091-3057 [Print] United States
PMID	7911577 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anticonvulsants Histamine Agonists Histamine H1 Antagonists Histamine H2 Antagonists Receptors, Histamine H1 Thiazoles 2-(2-aminoethyl)thiazole Histamine Pentylenetetrazole Dimaprit
Topics	Animals Anticonvulsants (administration & dosage, pharmacology) Dimaprit (administration & dosage, pharmacology) Dose-Response Relationship, Drug Electroshock Histamine (administration & dosage, pharmacology) Histamine Agonists (administration & dosage, antagonists & inhibitors, pharmacology) Histamine H1 Antagonists (administration & dosage, pharmacology) Histamine H2 Antagonists (administration & dosage, pharmacology) Injections, Intraventricular Male Mice Mice, Inbred Strains Pentylenetetrazole Receptors, Histamine H1 (drug effects) Seizures (chemically induced, prevention & control) Thiazoles (administration & dosage, antagonists & inhibitors, pharmacology)

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