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Expression of proliferating cell nuclear antigen in Wilms' tumors and other pediatric renal tumors: the correlation between histologic classification and proliferative activity.

Abstract
In order to estimate the proliferative activities in each prognosis predicting histologic type immunohistochemical studies for proliferating cell nuclear antigen (PCNA) have been performed on 27 pediatric renal tumors using formalin-fixed paraffin-embedded specimens. Image analyses determined the percentage of positive areas for PCNA, which were then represented in the PCNA score. The PCNA scores of nephroblastomas without anaplasia roughly correlated with the S phase fractions obtained by flow cytometry. The PCNA scores for each tumor were as follows; the renal specimens for the control study (n = 10, a mean +/- SD of 8.04 +/- 3.59%); the nephroblastomas without anaplasia (n = 15, 27.70 +/- 7.59%); the nephroblastomas with anaplasia (n = 3, 36.89 +/- 1.17%); the sarcomatous renal tumors (n = 5, 27.75 +/- 5.02); the renal cell carcinomas (n = 2, 28.31 +/- 0.86%), a congenital mesoblastic nephroma and a juxtaglomerular cell tumor (10.05 and 10.80%, respectively). The PCNA scores of the pediatric renal tumors correlated with neither the outcome of the patients nor the histologic groups in predicting the prognosis for such pediatric renal tumors.
AuthorsM Nagoshi, M Tsuneyoshi
JournalJournal of surgical oncology (J Surg Oncol) Vol. 55 Issue 2 Pg. 114-21 (Feb 1994) ISSN: 0022-4790 [Print] UNITED STATES
PMID7907158 (Publication Type: Journal Article)
Chemical References
  • Nuclear Proteins
  • Proliferating Cell Nuclear Antigen
Topics
  • Adolescent
  • Cell Division
  • Child
  • Child, Preschool
  • Female
  • Flow Cytometry
  • Humans
  • Immunohistochemistry
  • Infant
  • Infant, Newborn
  • Kidney Neoplasms (chemistry, pathology)
  • Male
  • Nuclear Proteins (analysis)
  • Proliferating Cell Nuclear Antigen
  • Retrospective Studies
  • S Phase
  • Wilms Tumor (chemistry, pathology)

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