Protective effect of DS-4574 on gastric mucosal injury induced by acidified ethanol in rats.

Abstract

We compared the protective effect of DS-4574, a peptidoleukotriene receptor antagonist with mast cell stabilizing action, on rat gastric mucosal injury induced by acidified ethanol to that of LY171883, a selective peptidoleukotriene receptor antagonist. Oral treatment with DS-4574 (1-10 mg/kg) or LY171883 (100 and 300 mg/kg) markedly suppressed this mucosal necrosis. Moreover, DS-4574 (10 mg/kg) significantly inhibited both mucosal edema and degranulation of mucosal mast cells. LY171883 (300 mg/kg) protected only from mucosal edema, but not degranulation of mucosal mast cells. These results suggest that DS-4574 possesses protective actions against gastric injury including the reduction of degranulation of mucosal mast cells, which are different from those of LY171883.

• Authors: Y Tabuchi, K Kawarabayashi, T Komada, K Furuhama
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 250 Issue 1 Pg. 197-9 (Nov 30 1993) ISSN: 0014-2999 [Print] Netherlands
• PMID: 7907021 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Acetophenones
• Autacoids
• Leukotriene Antagonists
• Pyrimidines
• Tetrazoles
• Triazoles
• DS 4574
• Ethanol
• LY 171883

Topics

• Acetophenones (pharmacology, therapeutic use)
• Animals
• Autacoids (antagonists & inhibitors)
• Cell Degranulation (drug effects)
• Edema (drug therapy)
• Ethanol (toxicity)
• Gastric Mucosa (drug effects, pathology)
• Hydrogen-Ion Concentration
• Leukotriene Antagonists
• Male
• Mast Cells (drug effects)
• Necrosis (drug therapy)
• Pyrimidines (pharmacology, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Tetrazoles (pharmacology, therapeutic use)
• Triazoles (pharmacology, therapeutic use)