Xanthonolol: a calcium channel and beta-adrenoceptor blocker with vasodilating properties.

Abstract

1. Xanthonolol (0.1-5.0 mg/kg, i.v.) reduced the blood pressure, heart rate, and L-isoproterenol (0.05 microgram/kg, i.v.)-induced tachycardia in rats. 2. In the isolated guinea-pig right atrium, xanthonolol (10(-6)-3 x 10(-4) M) produced long-lasting negative, inhibited L-isoproterenol-induced positive chronotropic effects, prevented the rate-increasing effects of increased extracellular Ca2+ (3.0-9.0 mM), and inhibited Ca2+ (3.0-9.0 mM)-induced heart rate-increase. 3. In the isolated guinea-pig thoracic aorta, the contractions induced by CaCl2 (0.1-5.0 mM) were inhibited by xanthonolol (10(-6)-10(-4) M). 4. Xanthonolol is suggested to have a calcium channel and beta adrenergic blocking effect with vasodilating properties.

• Authors: I J Chen, S J Liou, S S Liou, C N Lin
• Journal: General pharmacology (Gen Pharmacol) Vol. 24 Issue 6 Pg. 1425-33 (Nov 1993) ISSN: 0306-3623 [Print] England
• PMID: 7906662 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Antagonists
• Calcium Channel Blockers
• Vasodilator Agents
• Xanthenes
• Xanthones
• xanthonolol
• Isoproterenol
• Calcium Chloride

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Aorta, Thoracic (drug effects)
• Blood Pressure (drug effects)
• Calcium Channel Blockers (pharmacology)
• Calcium Chloride (pharmacology)
• Female
• Guinea Pigs
• Heart Rate (drug effects)
• In Vitro Techniques
• Isoproterenol (antagonists & inhibitors, pharmacology)
• Male
• Muscle Contraction (drug effects)
• Muscle, Smooth, Vascular (drug effects)
• Myocardial Contraction (drug effects)
• Rats
• Rats, Wistar
• Vasodilator Agents (pharmacology)
• Xanthenes (pharmacology)
• Xanthones