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Convulsant doses of cocaine alter immediate early gene and opioid peptide expression in rat limbic forebrain.

Abstract
Rats were treated with escalating doses of cocaine until they experienced a convulsion and were euthanized 1 or 3 h after the last injection. Quantitative in situ hybridization histochemistry revealed that c-fos and zif/268 mRNAs were induced at 1 h in many limbic structures and declined 3 h after cocaine-induced convulsions. Preprodynorphin and preproenkephalin signals increased in many of the same structures 3 h, but not 1 h, after cocaine-induced convulsions.
AuthorsT E Helton, J B Daunais, J F McGinty
JournalBrain research. Molecular brain research (Brain Res Mol Brain Res) Vol. 20 Issue 3 Pg. 285-8 (Nov 1993) ISSN: 0169-328X [Print] Netherlands
PMID7905595 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Convulsants
  • DNA-Binding Proteins
  • Early Growth Response Protein 1
  • Egr1 protein, rat
  • Enkephalins
  • Immediate-Early Proteins
  • Nerve Tissue Proteins
  • Protein Precursors
  • Proto-Oncogene Proteins c-fos
  • Transcription Factors
  • pre-prodynorphin
  • Dynorphins
  • preproenkephalin
  • Cocaine
Topics
  • Animals
  • Cocaine (pharmacology, toxicity)
  • Convulsants (pharmacology, toxicity)
  • DNA-Binding Proteins (biosynthesis, genetics)
  • Dynorphins (biosynthesis, genetics)
  • Early Growth Response Protein 1
  • Enkephalins (biosynthesis, genetics)
  • Gene Expression Regulation (drug effects)
  • Immediate-Early Proteins
  • In Situ Hybridization
  • Kindling, Neurologic
  • Limbic System (metabolism)
  • Male
  • Nerve Tissue Proteins (biosynthesis, genetics)
  • Protein Precursors (biosynthesis, genetics)
  • Proto-Oncogene Proteins c-fos (biosynthesis, genetics)
  • Rats
  • Seizures (chemically induced, genetics, metabolism)
  • Time Factors
  • Transcription Factors (biosynthesis, genetics)

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