Abstract |
Rats were treated with escalating doses of cocaine until they experienced a convulsion and were euthanized 1 or 3 h after the last injection. Quantitative in situ hybridization histochemistry revealed that c-fos and zif/268 mRNAs were induced at 1 h in many limbic structures and declined 3 h after cocaine-induced convulsions. Preprodynorphin and preproenkephalin signals increased in many of the same structures 3 h, but not 1 h, after cocaine-induced convulsions.
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Authors | T E Helton, J B Daunais, J F McGinty |
Journal | Brain research. Molecular brain research
(Brain Res Mol Brain Res)
Vol. 20
Issue 3
Pg. 285-8
(Nov 1993)
ISSN: 0169-328X [Print] Netherlands |
PMID | 7905595
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Convulsants
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Egr1 protein, rat
- Enkephalins
- Immediate-Early Proteins
- Nerve Tissue Proteins
- Protein Precursors
- Proto-Oncogene Proteins c-fos
- Transcription Factors
- pre-prodynorphin
- Dynorphins
- preproenkephalin
- Cocaine
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Topics |
- Animals
- Cocaine
(pharmacology, toxicity)
- Convulsants
(pharmacology, toxicity)
- DNA-Binding Proteins
(biosynthesis, genetics)
- Dynorphins
(biosynthesis, genetics)
- Early Growth Response Protein 1
- Enkephalins
(biosynthesis, genetics)
- Gene Expression Regulation
(drug effects)
- Immediate-Early Proteins
- In Situ Hybridization
- Kindling, Neurologic
- Limbic System
(metabolism)
- Male
- Nerve Tissue Proteins
(biosynthesis, genetics)
- Protein Precursors
(biosynthesis, genetics)
- Proto-Oncogene Proteins c-fos
(biosynthesis, genetics)
- Rats
- Seizures
(chemically induced, genetics, metabolism)
- Time Factors
- Transcription Factors
(biosynthesis, genetics)
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