Treatment of sympathetically maintained pain with terazosin.

Abstract

BACKGROUND AND OBJECTIVES:

alpha-adrenergic antagonists can be effective in the treatment of sympathetically maintained pain.

METHODS:

Oral terazosin was prescribed to treat sympathetically maintained pain refractory to other therapies.

RESULTS:

The authors describe a patient whose symptoms could not be controlled with commonly prescribed therapies, who obtained total relief of sympathetically maintained pain and vasospasm with terazosin, a new alpha 1 antagonist.

CONCLUSIONS:

Terazosin is effective in the treatment of sympathetically maintained pain when given once daily because of a long elimination half-time and a long duration of action. This may encourage better patient compliance than do other alpha antagonists of shorter effective duration.

• Authors: D S Stevens, V F Robins, H M Price
• Journal: Regional anesthesia (Reg Anesth) 1993 Sep-Oct Vol. 18 Issue 5 Pg. 318-21 ISSN: 0146-521X [Print] United States
• PMID: 7903550 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Terazosin
• Prazosin

Topics

• Adrenergic alpha-Antagonists (therapeutic use)
• Adult
• Female
• Humans
• Pain (drug therapy, physiopathology)
• Prazosin (analogs & derivatives, therapeutic use)
• Sympathetic Nervous System (physiopathology)