A postmarketing surveillance study of zopiclone in insomnia.

Abstract

Zopiclone, a novel cyclopyrrolone compound has recently become available for the treatment of insomnia in Singapore. Pharmacodynamic and pharmacokinetic studies have shown it to be an effective hypnotic with a good safety profile and minimal side-effects. The efficacy of Zopiclone was studied in a group of patients with insomnia (n = 40). The study group comprised patients with and without a psychiatric diagnosis. About two-thirds (65%) of the patients had been on hypnotics previously without relief of the insomnia. There was improvement in the various sleep parameters studied: sleep latency, sleep duration, night awakening, sleep quality, dreams, "day-after" effects. The drug was well-tolerated and only four patients experienced minor side-effects.

• Authors: R Mahendran, K T Chee, L H Peh, K E Wong, L Lim
• Journal: Singapore medical journal (Singapore Med J) Vol. 35 Issue 4 Pg. 390-3 (Aug 1994) ISSN: 0037-5675 [Print] India
• PMID: 7899899 (Publication Type: Journal Article)

Chemical References

• Azabicyclo Compounds
• Hypnotics and Sedatives
• Piperazines
• zopiclone

Topics

• Adult
• Azabicyclo Compounds
• Dreams (drug effects)
• Female
• Humans
• Hypnotics and Sedatives (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
• Male
• Middle Aged
• Neurotic Disorders (complications)
• Patient Satisfaction
• Piperazines (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
• Product Surveillance, Postmarketing
• Psychotic Disorders (complications)
• Singapore
• Sleep (drug effects)
• Sleep Initiation and Maintenance Disorders (drug therapy)
• Sleep Stages (drug effects)
• Wakefulness (drug effects)