Abstract | OBJECTIVE: To analyze electromyographic response and clinical effects after precurarization with vecuronium bromide (0.01 mg/Kg), also noting intubation conditions and the presence or not of fasciculations after administration of succinylcholine (1.5 mg/Kg). PATIENTS AND METHODS: A single precurarization dose of vecuronium was administered to 20 patients 5 minutes before anesthetic induction for general surgery. During this period we monitored neuromuscular transmission of the cubital nerve in the wrist by electromyography with a series of 4 stimuli, expressing each as the percentage of the first response and of the ratio T4/T1. We also recorded clinical repercussions. General anesthesia was then induced; after administration of succinylcholine, the presence or not of fasciculations was noted and intubation conditions were evaluated. RESULTS: The electromyographic response after precurarization was highly variable, as 4 different responses were recorded. We found potentiation phenomena in 20% of our patients, diminished response in 60%, fatigue phenomena in 15% and no change in 5%. Clinical signs noted were blurred vision and heavy eyelids. Fasciculations disappeared in 95% of the patients and intubation conditions were excellent. CONCLUSIONS:
Vecuronium at a precurarization dose produces highly varied but well-tolerated electromyographic responses. The drug is effective in eliminating fasciculations produced by succinylcholine and does not affect intubation conditions.
|
Authors | P López-Vidaur, A Seiz, C A de la Cruz, J R Fraile, A Criado |
Journal | Revista espanola de anestesiologia y reanimacion
(Rev Esp Anestesiol Reanim)
Vol. 42
Issue 2
Pg. 47-50
(Feb 1995)
ISSN: 0034-9356 [Print] Spain |
Vernacular Title | Respuesta electromiográfica de la precurarización con bromuro de vecuronio. |
PMID | 7899652
(Publication Type: Clinical Trial, English Abstract, Journal Article)
|
Chemical References |
- Vecuronium Bromide
- Succinylcholine
|
Topics |
- Adult
- Aged
- Electromyography
- Fasciculation
(chemically induced, physiopathology, prevention & control)
- Female
- Humans
- Male
- Middle Aged
- Succinylcholine
(adverse effects)
- Vecuronium Bromide
(therapeutic use)
|