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[Electromyographic response to precurarization with vecuronium bromide].

AbstractOBJECTIVE:
To analyze electromyographic response and clinical effects after precurarization with vecuronium bromide (0.01 mg/Kg), also noting intubation conditions and the presence or not of fasciculations after administration of succinylcholine (1.5 mg/Kg).
PATIENTS AND METHODS:
A single precurarization dose of vecuronium was administered to 20 patients 5 minutes before anesthetic induction for general surgery. During this period we monitored neuromuscular transmission of the cubital nerve in the wrist by electromyography with a series of 4 stimuli, expressing each as the percentage of the first response and of the ratio T4/T1. We also recorded clinical repercussions. General anesthesia was then induced; after administration of succinylcholine, the presence or not of fasciculations was noted and intubation conditions were evaluated.
RESULTS:
The electromyographic response after precurarization was highly variable, as 4 different responses were recorded. We found potentiation phenomena in 20% of our patients, diminished response in 60%, fatigue phenomena in 15% and no change in 5%. Clinical signs noted were blurred vision and heavy eyelids. Fasciculations disappeared in 95% of the patients and intubation conditions were excellent.
CONCLUSIONS:
Vecuronium at a precurarization dose produces highly varied but well-tolerated electromyographic responses. The drug is effective in eliminating fasciculations produced by succinylcholine and does not affect intubation conditions.
AuthorsP López-Vidaur, A Seiz, C A de la Cruz, J R Fraile, A Criado
JournalRevista espanola de anestesiologia y reanimacion (Rev Esp Anestesiol Reanim) Vol. 42 Issue 2 Pg. 47-50 (Feb 1995) ISSN: 0034-9356 [Print] Spain
Vernacular TitleRespuesta electromiográfica de la precurarización con bromuro de vecuronio.
PMID7899652 (Publication Type: Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Vecuronium Bromide
  • Succinylcholine
Topics
  • Adult
  • Aged
  • Electromyography
  • Fasciculation (chemically induced, physiopathology, prevention & control)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Succinylcholine (adverse effects)
  • Vecuronium Bromide (therapeutic use)

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