Abstract |
The effect of the Ca entry blocker nitrendipine, the antioxidant superoxide dismutase (SOD), and a combination of nitrendipine and superoxide dismutase on postischemic renal function was studied in four groups (n = 24) of rats. The rats in group 1 (n = 6) were the ischemic control and received 10 mL of 0.9% NaCl. Group II (n = 6) received SOD 7.0 mg/kg. Group III (n = 6) received nitrendipine 1 mg/kg. Group IV (n = 6) received nitrendipine 1 mg/kg and SOD 7 mg/kg. After administration, both kidneys were rendered ischemic by cross-clamping the renal vessels for 60 min. Comparison of 24-h creatinine clearance (CCr) for 3 days after reversal of ischemia revealed: (a) nitrendipine alone was the most effective in preserving renal function (p < .05); (b) SOD provided some degree of improvement, but only on day 3 (p < .05); (c) a similar result was detected using a combination of nitrendipine and SOD (p < .05); (d) there was no significant difference between SOD and nitrendipine nor between SOD and the combination of nitrendipine/SOD; (e) there was a significant improvement with nitrendipine when compared to the combination of nitrendipine/SOD (p < .05).
|
Authors | W K Jacobsen, R M Schell, J S Matsumura, D J Cole, G R Stier, R D Martin, B L Fandrich |
Journal | Renal failure
(Ren Fail)
Vol. 16
Issue 6
Pg. 697-705
(Nov 1994)
ISSN: 0886-022X [Print] England |
PMID | 7899581
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Nitrendipine
- Creatinine
- Superoxide Dismutase
|
Topics |
- Acute Kidney Injury
(drug therapy, etiology, physiopathology)
- Animals
- Creatinine
(blood, urine)
- Drug Therapy, Combination
- Ischemia
(drug therapy, physiopathology)
- Kidney
(blood supply, drug effects, physiopathology)
- Male
- Nitrendipine
(therapeutic use)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Superoxide Dismutase
(therapeutic use)
|