Comparison of a novel ETA receptor antagonist and phosphoramidon in renal ischemia.

Abstract

Infusion (0.46 mumol/kg/min) of the endothelin (ET)-converting-enzyme inhibitor, phosphoramidon (P), protected function and structure after 30 min renal ischemia in rats more than treatment (5 mumol/kg/min) with the ETA receptor antagonist, BMS-182874 (B). The glomerular filtration rate (GFR; 0.7 +/- 0.12 ml/min) and renal plasma flow (RPF) decreased approximately 40% at 2 h reflow versus controls (C: 1.2 +/- 0.12). B weakly protected the GFR (0.8 +/- 0.07 ml/min); P restored it (1.1 +/- 0.05). Both compounds reduced tubular injury at 2 h reflow; P ameliorated glomerular changes. At 24 h the GFR (0.6 +/- 0.06 ml/min) and RPF decreased 67% versus C (1.8 +/- 0.08). B did not protect the GFR and RPF. P partially protected the GFR (0.9 +/- 0.07 ml/min) but not RPF, and reduced tubular injury. The results suggest that both ETA and non-ETA receptors mediate ET-induced changes in ischemic renal failure.

• Authors: J E Bird, M L Webb, A J Wasserman, E C Liu, M R Giancarli, S K Durham
• Journal: Pharmacology (Pharmacology) Vol. 50 Issue 1 Pg. 9-23 (Jan 1995) ISSN: 0031-7012 [Print] Switzerland
• PMID: 7899482 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dansyl Compounds
• Endothelin Receptor Antagonists
• Glycopeptides
• Iodine Radioisotopes
• 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide
• Creatinine
• phosphoramidon

Topics

• Animals
• Blood Pressure (drug effects)
• Creatinine (blood)
• Dansyl Compounds (pharmacology)
• Endothelin Receptor Antagonists
• Glomerular Filtration Rate (drug effects)
• Glycopeptides (pharmacology)
• Iodine Radioisotopes
• Ischemia (drug therapy)
• Kidney (blood supply, physiopathology)
• Male
• Rats
• Rats, Sprague-Dawley
• Renal Plasma Flow (drug effects)
• Time Factors