Abstract |
Piroxantrone, a synthetic intercalating agent, was studied in patients with advanced, measurable gastric adenocarcinoma who had not received prior chemotherapy. The starting piroxantrone dose was 150 mg/m2 given intravenously over 1 hour on day 1 and repeated every 21 days. Response and toxicity could be evaluated in 15 patients. No complete, partial, or minor responses were observed. Toxic effects included granulocytopenia, anemia, vomiting, nausea, anorexia, fatigue, stomatitis, alopecia, hyperbilirubinemia, and increased alkaline phosphatase levels. At the stated dose and schedule, piroxantrone does not possess significant activity against advanced gastric cancer.
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Authors | R Pazdur, B Bready, A J Scalzo, J E Brandof, D R Close, S Kolbye, R J Winn |
Journal | Investigational new drugs
(Invest New Drugs)
Vol. 12
Issue 3
Pg. 263-5
( 1994)
ISSN: 0167-6997 [Print] United States |
PMID | 7896547
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anthraquinones
- Antineoplastic Agents
- Pyrazoles
- piroxantrone
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Topics |
- Adenocarcinoma
(drug therapy)
- Adult
- Aged
- Aged, 80 and over
- Anemia
(chemically induced)
- Anthraquinones
(adverse effects, therapeutic use)
- Antineoplastic Agents
(therapeutic use)
- Fatigue
(chemically induced)
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Metastasis
- Pyrazoles
(adverse effects, therapeutic use)
- Stomach Neoplasms
(drug therapy)
- Vomiting
(chemically induced)
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