Abstract |
Twenty-eight patients, aged 58 years or more and with clinical and radiological evidence of degenerative osteoarthritis of the knee joint, were entered into an open 6-month pilot study. Patients received a single intra-articular injection of tenoxicam (20 mg) into the affected knee with rigid adherence to aseptic technique. Efficacy was assessed in 25 evaluable patients according to three parameters: pain, hydrarthrosis and range of joint movement. Ten days after injection, 40% of patients (10/25) had greatly improved pain, 24% (6/25) showed improvement, while 12% (3/25) experienced a worsening of their pain; the remaining patients (24%) showed no change. Ten days after injection, the percentage of patients with hydrarthrosis was reduced from 43% (12/28) to 20% (5/25). Range of movement of the affected joint 1 month after injection was increased in 60% (15/25) of patients, decreased in 16% (4/25), and unchanged in 24% (6/25). Two patients reported a slight allergic reaction to the injection; no other side-effects were detected. The results of this pilot study justify investigating the efficacy of intra-articular tenoxicam in controlled double-blind studies.
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Authors | N P Papathanassiou |
Journal | The Journal of international medical research
(J Int Med Res)
1994 Nov-Dec
Vol. 22
Issue 6
Pg. 332-7
ISSN: 0300-0605 [Print] England |
PMID | 7895896
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Piroxicam
- tenoxicam
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Topics |
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Female
- Humans
- Injections, Intra-Articular
- Knee Joint
(diagnostic imaging)
- Male
- Middle Aged
- Movement
- Osteoarthritis
(diagnostic imaging, drug therapy, physiopathology)
- Pain Measurement
- Pilot Projects
- Piroxicam
(administration & dosage, analogs & derivatives, therapeutic use)
- Radiography
- Time Factors
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