Corticotropin release inhibiting factor is encoded within prepro-TRH.

Abstract

Corticotropin synthesis and secretion is under negative feedback regulation by glucocorticoids. In addition a hypothalamic factor inhibiting ACTH synthesis and secretion, named corticotropin release inhibiting factor (CRIF), has been postulated but not identified. Here we report that transient transfection of a rat prepro-TRH cDNA into the mouse anterior pituitary tumor cell line AtT-20 inhibits the synthesis and secretion of both basal and CRH-stimulated ACTH. Thus, CRIF appears to be encoded by the same precursor as TRH, suggesting a coordinated regulation of pituitary-adrenal and pituitary-thyroid functions.

• Authors: E Redei, H Hilderbrand, F Aird
• Journal: Endocrinology (Endocrinology) Vol. 136 Issue 4 Pg. 1813-6 (Apr 1995) ISSN: 0013-7227 [Print] United States
• PMID: 7895696 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Complementary
• Protein Precursors
• prepro-thyrotropin-releasing hormone
• Thyrotropin-Releasing Hormone
• Adrenocorticotropic Hormone
• Corticotropin-Releasing Hormone

Topics

• Adrenocorticotropic Hormone (antagonists & inhibitors, biosynthesis, metabolism)
• Animals
• Corticotropin-Releasing Hormone (pharmacology)
• DNA, Complementary (genetics)
• Mice
• Pituitary Gland, Anterior (metabolism)
• Pituitary Neoplasms
• Protein Precursors (genetics)
• Thyrotropin-Releasing Hormone (genetics)
• Transfection
• Tumor Cells, Cultured