Abstract | OBJECTIVE: METHODS: APF- IgA were screened in 80 sera from patients with active RA, prospectively and consecutively selected over an 8-month period. Sera from 22 patients with Sjögren's syndrome and 50 with lupus were also studied retrospectively for APF- IgG and IgA. RESULTS: APF- IgA were found at a 1:10 dilution or above in 31 RA sera (39%), which were all positive for APF- IgG as well at higher titers. In the 64 sera positive for APF no correlations were found between APF- IgA and IgA or immune complexes- IgA, latex, the Rose-Waaler test and RF- IgA. Conversely, an association of APF- IgA was found with both APF- IgG (p < 0.0001) and anti-stratum corneum of rat esophagus (ASC)- IgG (p < 0.0001). APF- IgA, though correlated with the presence of secondary sicca syndrome in RA (p = 0.0023), was not more frequent (5/22) in primary Sjögren's sera. CONCLUSIONS: RF- IgA and APF- IgA are not correlated. Despite its localization in the mucosae, the target antigen for APF elicit fewer IgA antibodies in RA than does the RF target.
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Authors | J M Berthelot, B Bendaoud, Y Maugars, M Audrain, A Prost, P Youinou |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
1994 Nov-Dec
Vol. 12
Issue 6
Pg. 615-9
ISSN: 0392-856X [Print] Italy |
PMID | 7895395
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Antinuclear
- Biomarkers
- Filaggrin Proteins
- Immunoglobulin A
- Immunoglobulin G
- Intermediate Filament Proteins
- antiperinuclear factor
- Rheumatoid Factor
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Topics |
- Adult
- Aged
- Animals
- Antibodies, Antinuclear
(immunology)
- Arthritis, Rheumatoid
(immunology)
- Biomarkers
(blood)
- Female
- Filaggrin Proteins
- Humans
- Immunoglobulin A
(immunology)
- Immunoglobulin G
(immunology)
- Intermediate Filament Proteins
(analysis)
- Lupus Erythematosus, Systemic
(immunology)
- Male
- Middle Aged
- Mouth Mucosa
(pathology)
- Predictive Value of Tests
- Prospective Studies
- Rats
- Rats, Wistar
- Retrospective Studies
- Rheumatoid Factor
(immunology)
- Sjogren's Syndrome
(metabolism)
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