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Antiperinuclear factor of the IgA isotype in active rheumatoid arthritis.

AbstractOBJECTIVE:
For rheumatoid arthritis (RA), antiperinuclear factor (APF) is as efficient a marker as rheumatoid factor (RF). However, the prevalence and significance of APF of the IgA isotype in active RA, as well as its correlation with RF-IgA, have not been determined. Our goal was to obtain information on these points.
METHODS:
APF-IgA were screened in 80 sera from patients with active RA, prospectively and consecutively selected over an 8-month period. Sera from 22 patients with Sjögren's syndrome and 50 with lupus were also studied retrospectively for APF-IgG and IgA.
RESULTS:
APF-IgA were found at a 1:10 dilution or above in 31 RA sera (39%), which were all positive for APF-IgG as well at higher titers. In the 64 sera positive for APF no correlations were found between APF-IgA and IgA or immune complexes-IgA, latex, the Rose-Waaler test and RF-IgA. Conversely, an association of APF-IgA was found with both APF-IgG (p < 0.0001) and anti-stratum corneum of rat esophagus (ASC)-IgG (p < 0.0001). APF-IgA, though correlated with the presence of secondary sicca syndrome in RA (p = 0.0023), was not more frequent (5/22) in primary Sjögren's sera.
CONCLUSIONS:
RF-IgA and APF-IgA are not correlated. Despite its localization in the mucosae, the target antigen for APF elicit fewer IgA antibodies in RA than does the RF target.
AuthorsJ M Berthelot, B Bendaoud, Y Maugars, M Audrain, A Prost, P Youinou
JournalClinical and experimental rheumatology (Clin Exp Rheumatol) 1994 Nov-Dec Vol. 12 Issue 6 Pg. 615-9 ISSN: 0392-856X [Print] Italy
PMID7895395 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Antinuclear
  • Biomarkers
  • Filaggrin Proteins
  • Immunoglobulin A
  • Immunoglobulin G
  • Intermediate Filament Proteins
  • antiperinuclear factor
  • Rheumatoid Factor
Topics
  • Adult
  • Aged
  • Animals
  • Antibodies, Antinuclear (immunology)
  • Arthritis, Rheumatoid (immunology)
  • Biomarkers (blood)
  • Female
  • Filaggrin Proteins
  • Humans
  • Immunoglobulin A (immunology)
  • Immunoglobulin G (immunology)
  • Intermediate Filament Proteins (analysis)
  • Lupus Erythematosus, Systemic (immunology)
  • Male
  • Middle Aged
  • Mouth Mucosa (pathology)
  • Predictive Value of Tests
  • Prospective Studies
  • Rats
  • Rats, Wistar
  • Retrospective Studies
  • Rheumatoid Factor (immunology)
  • Sjogren's Syndrome (metabolism)

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