Effects of AETT-induced neuronal ceroid lipofuscinosis on learning ability in rats.

Abstract

The behavioral effects of ceroid-lipofuscin accumulation, induced by intraperitoneal administration of acetyl-ethyl-tetramethyl-tetralin (AETT) in Wistar rats for 3 months, were examined in the present studies. A significant increase in neuronal ceroidlipofuscin was demonstrated neuropathologically as well as morphometrically. Although the AETT-intoxicated rats showed neither alteration of locomotor activity nor shock sensitivity, a significant impairment of learning ability, especially an acquisition trial in passive avoidance tests, was observed. Results of the present studies indicate the possibility that a diffuse lipofuscin accumulation causes a learning impairment in rats. The results also imply the possibility of a significant role of age-related lipofuscin accumulation in the dementing processes of human especially in the elderly.

• Authors: A Furuhashi, Y Akasaki, M Sato, K Miyoshi
• Journal: The Japanese journal of psychiatry and neurology (Jpn J Psychiatry Neurol) Vol. 48 Issue 3 Pg. 645-53 (Sep 1994) ISSN: 0912-2036 [Print] Japan
• PMID: 7891432 (Publication Type: Journal Article)

Chemical References

• Tetrahydronaphthalenes

Topics

• Animals
• Avoidance Learning (drug effects)
• Electroshock
• Fluorescence
• Hippocampus (drug effects)
• Memory (drug effects)
• Motor Activity (drug effects)
• Neuronal Ceroid-Lipofuscinoses (chemically induced)
• Olfactory Pathways (drug effects)
• Rats
• Rats, Wistar
• Tetrahydronaphthalenes (pharmacology)