Abstract |
Plasma concentrations of pancuronium bromide have been studied in seven surgical patients following a 6 mg intravenous bolus injection of the drug for neuromuscular blockade. Concurrently, evoked muscle twitch response was monitored for each patient as a measure of the pharmacodynamic effect of the drug. The plasma decay curve for pancuronium was found to be biphasic and after rigorous statistical analysis the data were interpreted according to a 2-compartment open model. The half-life of the beta-phase varied between 89.5 and 161.5 min. The apparent volume of distribution of the central compartment ranged from 62.9 to145.5 ml/kg and the plasma clearance from 57.6 to 187.3 ml/min. At the first sign of recovery from neuro-muscular blockade the mean pancuronium plasma level was found to be 0.218 mcg/ml. The mean duration of action as measured from time of onset of paralysis to 20% recovery was 83.4 min with the plasma level at 20% being 0.169 mcg/ml corresponding to 45.4% of dose remaining to be eliminated from the body.
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Authors | A A Somogyi, C A Shanks, E J Triggs |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 10
Issue 5
Pg. 367-72
(Sep 30 1976)
ISSN: 0031-6970 [Print] Germany |
PMID | 789085
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Anesthesia, Intravenous
- Clinical Trials as Topic
- Female
- Half-Life
- Humans
- Male
- Middle Aged
- Models, Biological
- Pancuronium
(blood, metabolism, pharmacology)
- Surgical Procedures, Operative
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