Effect of an angiotensin II receptor antagonist, TCV-116, on rat carotid artery neointimal formation after balloon injury.

Abstract	Arterial injury by a balloon catheter produces marked smooth muscle cell proliferation and the participation of angiotensin II in this response has been suggested. In this study, we examined the effect of a novel angiotensin II type I receptor antagonist, TCV-116, on neointimal formation after rat carotid artery balloon injury. Oral administration of TCV-116 at doses of 1, 5 or 10 mg/kg/day significantly reduced the cross-sectional intimal area by 30%, 46% and 54%, respectively, and reduced the ratio of the intimal to medial cross-sectional areas by 23%, 41% and 50%. An angiotensin-converting enzyme inhibitor, lisinopril, had an effect similar to that of TCV-116. The effect of both drugs was significantly correlated with the reduction of both blood pressure and cardiac hypertrophy. We conclude that TCV-116 can prevent neointimal formation after balloon injury as well as reducing blood pressure and preventing cardiac hypertrophy.
Authors	H Kino, J Hama, T Takenaka, K Sugimura, K Kamoi, S Shimada, Y Yamamoto, S Nagata, M Horiuchi, R Katori
Journal	Blood pressure. Supplement (Blood Press Suppl) Vol. 5 Pg. 43-8 ( 1994) ISSN: 0803-8023 [Print] Sweden
PMID	7889200 (Publication Type: Comparative Study, Journal Article)
Chemical References	Angiotensin Receptor Antagonists Antihypertensive Agents Benzimidazoles Biphenyl Compounds Prodrugs Tetrazoles Lisinopril candesartan cilexetil
Topics	Angiotensin Receptor Antagonists Animals Antihypertensive Agents (therapeutic use) Arteriosclerosis (etiology, pathology, prevention & control) Benzimidazoles (therapeutic use) Biphenyl Compounds (therapeutic use) Blood Pressure (drug effects) Carotid Artery Diseases (etiology, pathology, prevention & control) Carotid Artery, Common (drug effects, pathology) Catheterization (adverse effects) Hypertension (drug therapy) Lisinopril (therapeutic use) Male Prodrugs (therapeutic use) Rats Rats, Inbred SHR Rats, Sprague-Dawley Tetrazoles Tunica Intima (drug effects, pathology)

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