Endotracheal tolazoline for severe persistent pulmonary hypertension of the newborn.

Abstract

The condition of a neonate with severe persistent pulmonary hypertension who became severely hypoxic and acidotic despite intensive conventional treatment improved dramatically after endotracheal administration of tolazoline. This logical mode of administration of vasodilator therapy for this condition has not been reported before. It seemed to be life saving in this case and it warrants further clinical trial.

• Authors: J C Welch, J M Bridson, J L Gibbs
• Journal: British heart journal (Br Heart J) Vol. 73 Issue 1 Pg. 99-100 (Jan 1995) ISSN: 0007-0769 [Print] England
• PMID: 7888273 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tolazoline

Topics

• Acidosis (drug therapy)
• Administration, Topical
• Humans
• Hyaline Membrane Disease (complications)
• Hypertension, Pulmonary (complications, drug therapy)
• Hypoxia (drug therapy)
• Infant, Newborn
• Infusions, Intravenous
• Male
• Tolazoline (administration & dosage)
• Trachea