Abstract | BACKGROUND: OBSERVATIONS: Lesions measured 0.8 x 0.5 to 16.0 x 15.0 cm. Histologically, all cases resembled mycosis fungoides-type cutaneous T-cell lymphoma and phenotypic analysis supported their designation as an epidermotropic T-cell process. Phenotypic aberrancy was not noted on immunohistochemical analysis of paraffin-embedded tissue. Three of four patients with available fresh-frozen tissue specimens demonstrated reduced or absent expression of CD7 (Leu-9) and/or Leu-8, while loss of the pan-T-cell markers CD2, CD3, and CD5 was not observed. Only in half these patients was a lesional predominance of CD4+ T-cells revealed. Germline DNA was detected in a lesional skin specimen obtained from one patient tested for T-cell receptor gene rearrangements. After treatment, the observation of disease-free periods ranging from 18 months to 17 years (mean, 5.9 years) reinforces the view that Woringer-Kolopp disease is a focal pathologic event with a favorable prognosis. No patient experienced a local recurrence or distant spread of the disease. CONCLUSION:
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Authors | M K Burns, L S Chan, K D Cooper |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 131
Issue 3
Pg. 325-9
(Mar 1995)
ISSN: 0003-987X [Print] United States |
PMID | 7887663
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Female
- Follow-Up Studies
- Humans
- Lymphatic Diseases
(immunology)
- Male
- Middle Aged
- Mycosis Fungoides
(immunology)
- Skin Neoplasms
(immunology)
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