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Itraconazole for the treatment of histoplasmosis in cats.

Abstract
Eight cats with histoplasmosis were treated with itraconazole at 5 mg/kg per dose PO bid. There were multiple sites of infection, and 2 of the cats had hypercalcemia that was attributed to the histoplasmosis. All 8 cats were eventually cured, but 2 cats experienced recurrences of disease after completion of therapy, requiring 2 to 3 additional months of itraconazole. There were no clinically relevant adverse effects during treatment. Although a limited number of cats were treated, the study suggests that itraconazole is a well-tolerated and effective drug for the treatment of histoplasmosis in the cat.
AuthorsR D Hodges, A M Legendre, L G Adams, M D Willard, R P Pitts, K Monce, C C Needels, H Ward
JournalJournal of veterinary internal medicine (J Vet Intern Med) 1994 Nov-Dec Vol. 8 Issue 6 Pg. 409-13 ISSN: 0891-6640 [Print] United States
PMID7884727 (Publication Type: Journal Article)
Chemical References
  • Itraconazole
Topics
  • Administration, Oral
  • Animals
  • Bone Marrow (microbiology)
  • Bronchoalveolar Lavage Fluid (microbiology)
  • Cat Diseases (drug therapy, microbiology)
  • Cats
  • Drug Tolerance
  • Female
  • Histoplasma (isolation & purification)
  • Histoplasmosis (drug therapy, veterinary)
  • Itraconazole (administration & dosage, therapeutic use)
  • Male
  • Recurrence
  • Treatment Outcome

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