Abstract |
Eight cats with histoplasmosis were treated with itraconazole at 5 mg/kg per dose PO bid. There were multiple sites of infection, and 2 of the cats had hypercalcemia that was attributed to the histoplasmosis. All 8 cats were eventually cured, but 2 cats experienced recurrences of disease after completion of therapy, requiring 2 to 3 additional months of itraconazole. There were no clinically relevant adverse effects during treatment. Although a limited number of cats were treated, the study suggests that itraconazole is a well-tolerated and effective drug for the treatment of histoplasmosis in the cat.
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Authors | R D Hodges, A M Legendre, L G Adams, M D Willard, R P Pitts, K Monce, C C Needels, H Ward |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
1994 Nov-Dec
Vol. 8
Issue 6
Pg. 409-13
ISSN: 0891-6640 [Print] United States |
PMID | 7884727
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Animals
- Bone Marrow
(microbiology)
- Bronchoalveolar Lavage Fluid
(microbiology)
- Cat Diseases
(drug therapy, microbiology)
- Cats
- Drug Tolerance
- Female
- Histoplasma
(isolation & purification)
- Histoplasmosis
(drug therapy, veterinary)
- Itraconazole
(administration & dosage, therapeutic use)
- Male
- Recurrence
- Treatment Outcome
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