6-Amino-6-deoxyascorbic acid induces apoptosis in human tumor cells.

Abstract

6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell growth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, drastic morphological changes were found. Although image analysis did not show a difference in p53 and c-myc gene expression, the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death.

• Authors: M Grdisa, M Kralj, M Eckert-Maksić, Z B Maksić, K Pavelić
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 121 Issue 2 Pg. 98-102 ( 1995) ISSN: 0171-5216 [Print] Germany
• PMID: 7883782 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 6-amino-6-deoxyascorbic acid
• Antineoplastic Agents
• Proto-Oncogene Proteins c-myc
• Tumor Suppressor Protein p53
• DNA
• Ascorbic Acid

Topics

• Antineoplastic Agents (pharmacology)
• Apoptosis (drug effects)
• Ascorbic Acid (analogs & derivatives, pharmacology)
• DNA (metabolism)
• Humans
• Neoplasms (pathology)
• Proto-Oncogene Proteins c-myc (analysis)
• Tumor Cells, Cultured
• Tumor Suppressor Protein p53 (analysis)