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Diagnosis and treatment of Amanita phalloides-type mushroom poisoning: use of thioctic acid.

Abstract
The number of cases of mushroom poisoning is increasing as a result of the increasing popularity of "wild" mushroom consumption. Amanitin and phalloidin cytotoxins found in some Amanita and Galerina species produce the most severe and frequent life-threatening symptoms of Amanita phalloidestype poisoning. Delay in onset of symptoms, individual susceptibility variation and lack of rapid and reliable identification have contributed to the significant morbidity and mortality of this type of poisoning.A rapid chromatographic assay for identifying the potent cytotoxins and apparently successful management using thioctic acid of two cases of A. phalloides-type mushroom poisoning are reported. All known cases of A. phalloides-type mushroom poisoning treated with thioctic acid in the United States are summarized.
AuthorsC E Becker, T G Tong, U Boerner, R L Roe, A T ScoTT, M B MacQuarrie, F Bartter
JournalThe Western journal of medicine (West J Med) Vol. 125 Issue 2 Pg. 100-9 (Aug 1976) ISSN: 0093-0415 [Print] United States
PMID788340 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Thioctic Acid
Topics
  • Adolescent
  • Adult
  • Aged
  • Amanita
  • Animals
  • Child
  • Dogs
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mushroom Poisoning (diagnosis, drug therapy)
  • Thioctic Acid (therapeutic use)

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