Histamine depletion in brain caused by treatment with (S)alpha-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons.

Abstract

The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

• Authors: K Sugimoto, K Abe, T H Lee, E Sakurai, K Yanai, K Kogure, Y Itoyama, T Watanabe
• Journal: Brain research (Brain Res) Vol. 666 Issue 2 Pg. 279-83 (Dec 15 1994) ISSN: 0006-8993 [Print] Netherlands
• PMID: 7882040 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histamine Antagonists
• Methylhistidines
• alpha-fluoromethylhistidine
• Histamine

Topics

• Animals
• Brain (drug effects, metabolism)
• Brain Ischemia (pathology)
• Gerbillinae
• Hippocampus (drug effects, pathology)
• Histamine (metabolism)
• Histamine Antagonists (pharmacology)
• Male
• Methylhistidines (pharmacology)
• Neurons (drug effects, pathology)