[Studies on the efficacy and safety of biapenem (L-627) against infections in pediatrics].

Abstract

The efficacy and the safety of biapenem (L-627), a new carbapenem antibiotic, against infections in pediatrics were studied. The obtained results are summarized as follows. 1. L-627 at dose levels of 5.4 mg/kg to 12.4 mg/kg (daily doses of 16.2 mg/kg to 37.2 mg/kg) was administered by intravenous drip infusion 3 times daily for 5 to 7 days to 2 cases of pneumonia, 3 cases of skin and soft-tissue infections and 1 case of urinary tract infection for a total of 6 cases. As results, all the cases showed good or better responses including 4 excellent and 2 good results. Bacteriological efficacies in all of the 3 eligible cases were assessed as "eradicated". 2. As for the safety, a decrease in the WBC count and slight elevation of GOT and GPT were observed in 1 case as abnormal changes in the laboratory tests results, only incidence of side effect observed was the eruption in 1 case. 3. The results above indicate that L-627 is useful for the treatment of general infections in pediatrics.

• Authors: T Haruta, S Kuroki, K Ohkura, H Nikami, T Nishio, Y Kobayashi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 47 Issue 12 Pg. 1723-7 (Dec 1994) ISSN: 0368-2781 [Print] Japan
• PMID: 7877253 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Thienamycins
• biapenem

Topics

• Bacterial Infections (drug therapy)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Infusions, Intravenous
• Leukopenia (chemically induced)
• Liver (drug effects)
• Male
• Skin Diseases, Infectious (drug therapy)
• Thienamycins (administration & dosage, adverse effects, therapeutic use)
• Urinary Tract Infections (drug therapy)