Efficacy of moxidectin oral gel against Onchocerca cervicalis microfilariae.

Abstract

During a series of dose-titration experiments designed to evaluate the efficacy of moxidectin oral gel against equine gastrointestinal parasites, infection with Onchocerca cervicalis was diagnosed in 25 of 82 ponies prior to treatment. Microfilariae were identified in full-thickness skin biopsies taken from the ventral midline. Treatment with moxidectin in single doses of 300, 400, or 500 micrograms/kg of body weight was 100% effective in eliminating microfilariae from 20 skin biopsies taken 14 days posttreatment, whereas 5 microfilaria-positive ponies in 2 control groups remained positive following placebo treatment. No adverse reaction was seen in any pony following treatment with moxidectin or the vehicle control.

• Authors: C M Monahan, M R Chapman, D D French, T R Klei
• Journal: The Journal of parasitology (J Parasitol) Vol. 81 Issue 1 Pg. 117-8 (Feb 1995) ISSN: 0022-3395 [Print] United States
• PMID: 7876966 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Anti-Bacterial Agents
• Gels
• Macrolides
• moxidectin

Topics

• Administration, Oral
• Animals
• Anthelmintics (administration & dosage, therapeutic use)
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Gels
• Horse Diseases (drug therapy)
• Horses
• Macrolides
• Microfilariae (isolation & purification)
• Onchocerca (isolation & purification)
• Onchocerciasis (drug therapy, veterinary)
• Skin (parasitology)