Influence of food and body weight on the pharmacokinetics of penticainide.

Abstract

The pharmacokinetics of penticainide, a class Ic antiarrhythmic drug, was studied in 16 healthy adults (eight males and eight females) after a single 300-mg oral dose in fasting conditions and with a standard meal. Penticainide concentrations in plasma and urine were measured by hplc. The pharmacokinetic parameters of penticainide including Cmax, tmax, AUC and t1/2 were not significantly altered in the presence of food. AUC values (mean +/- sd) were 50.68 +/- 10.8 mg.h.l-1 and 49.52 +/- 9.87 mg.h.l-1 in the absence and presence of food, respectively. However, a significant difference was observed between males and females in both fasting and fed conditions with a higher value of the apparent oral clearance in the second group. The values of apparent oral clearance, expressed in weight-normalized units were 1.33 +/- 0.35 ml.mn-1.kg-1 (male) and 1.93 +/- 0.34 ml.mn-1.kg-1 (female) in fast conditions (P < 0.01) and 1.38 +/- 0.28 ml.mn-1.kg-1 (male) and 1.93 +/- 0.49 ml.mn-1.kg-1 (female) in fed conditions (P < 0.02), respectively. The pharmacokinetics of penticainide is not modified by the presence of food, but an influence of body weight may be considered.

• Authors: D Berdaï, F Demotes-Mainard, F Philip, G Vinçon, R Montels, J Necciari, B Bannwarth
• Journal: Fundamental & clinical pharmacology (Fundam Clin Pharmacol) Vol. 8 Issue 5 Pg. 453-7 ( 1994) ISSN: 0767-3981 [Print] England
• PMID: 7875640 (Publication Type: Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Propylamines
• Pyridines
• propisomide

Topics

• Adult
• Analysis of Variance
• Anti-Arrhythmia Agents (pharmacokinetics)
• Body Weight (physiology)
• Fasting (metabolism)
• Female
• Food-Drug Interactions
• Humans
• Male
• Propylamines (pharmacokinetics)
• Pyridines (pharmacokinetics)
• Sex Factors