Abstract | BACKGROUND/AIMS: METHODS: Patients with AIDS and enteric cryptosporidiosis (n = 12), other enteric infections (n = 10), and no identifiable enteric pathogen (n = 10) and human immunodeficiency virus-seronegative controls (n = 18) were studied. The number of intestinal IgA and IgM plasma cells of the duodenal lamina propria mucosa and total and anti-Cryptosporidium IgA, IgM, and IgG were measured in serum and feces. RESULTS: Although not significantly increased, the number of IgA and IgM plasma cells was greater in patients with AIDS (n = 20) than in controls (n = 5). In feces, total IgA outputs and specific anti-Cryptosporidium IgA levels were significantly higher in patients with AIDS and cryptosporidiosis than in the two other groups of patients with AIDS (P < 0.05 and P < 0.01, respectively) and controls (P < 0.001 and P < 0.01, respectively). Total fecal IgM output and specific anti-Cryptosporidium IgM coproantibodies were increased only in the Cryptosporidium-infected patients relative to the controls (P < 0.05). CONCLUSIONS: Despite the development of pathogen-specific mucosal antibody responses, patients with AIDS and cryptosporidiosis fail to clear the parasite.
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Authors | Y Benhamou, N Kapel, C Hoang, H Matta, D Meillet, D Magne, M Raphael, M Gentilini, P Opolon, J G Gobert |
Journal | Gastroenterology
(Gastroenterology)
Vol. 108
Issue 3
Pg. 627-35
(Mar 1995)
ISSN: 0016-5085 [Print] United States |
PMID | 7875465
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Protozoan
- Immunoglobulins
- alpha 1-Antitrypsin
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Topics |
- Acquired Immunodeficiency Syndrome
(complications, immunology)
- Adult
- Animals
- Antibodies, Protozoan
(analysis)
- Antibody Formation
- Cell Count
- Cryptosporidiosis
(complications)
- Cryptosporidium
(immunology)
- Electrophoresis, Polyacrylamide Gel
- Feces
(chemistry)
- Female
- Humans
- Immunoblotting
- Immunoglobulins
(analysis)
- Intestinal Mucosa
(immunology, metabolism)
- Male
- Middle Aged
- Plasma Cells
(pathology)
- alpha 1-Antitrypsin
(metabolism)
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