Sequence analysis and exclusion of phosducin as the gene for the recessive retinal degeneration of the Abyssinian cat.

Abstract

Phosducin was evaluated as a candidate gene for the recessive retinal degeneration in the Abyssinan cat, rdAc, using reverse transcription and polymerase chain amplification. The nucleotide sequence of the cat phosducin coding region was determined except for 23 bp at the 5' end. Single-strand conformation analysis of a silent polymorphism within the coding region established the nonlinkage of the phosducin gene with the rdAc locus.

• Authors: M B Gorin, A C To, K Narfstrom
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1260 Issue 3 Pg. 323-7 (Feb 21 1995) ISSN: 0006-3002 [Print] Netherlands
• PMID: 7873608 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Eye Proteins
• GTP-Binding Protein Regulators
• Phosphoproteins
• phosducin
• DNA
• Protein Kinases

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Cats
• DNA
• Eye Proteins (genetics)
• GTP-Binding Protein Regulators
• Genes, Recessive
• Molecular Sequence Data
• Phosphoproteins (genetics)
• Polymerase Chain Reaction
• Protein Kinases (genetics)
• Retinal Degeneration (genetics)