Evidence exists implicating the epidermal ultraviolet B (UVB) photoproduct cis-
urocanic acid as an immunogenic mediator of the systemic suppression of T cell-mediated immunity by UVB exposure. Cis-
urocanic acid appears to act via
histamine receptor pathways, and
histamine receptor antagonists and other
imidazole ring compounds may modify its immune suppressing action. A component of the food coloring substance
ammonia caramel,
2-acetyl-4-tetrahydroxybutylimidazole (THI), which is known to cause
lymphopenia in rats, appears to suppress immunity by a similar pathway when the
contact hypersensitivity reaction has been the immune function assay in mice. The induction of
lymphopenia in rats by THI is inhibited by the
vitamin pyridoxine. This study demonstrates that the suppression of
contact hypersensitivity in mice by UVB radiation, cis-
urocanic acid, or THI is strongly inhibited by supplemental
pyridoxine, fed at 30 mg/kg diet, in comparison with the normal diet, which supplies 7
mg pyridoxine/kg diet. These results suggest that
pyridoxine competes with cis-
urocanic acid and THI for the same binding site or receptor, which we postulate to be a
histamine-like T lymphocyte receptor, and that a role may exist for the control of photoimmunosuppression by this
vitamin.