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The protective role of pyridine N-oxide in cytotoxicity and genotoxicity of hydrogen peroxide and adriamycin.

Abstract
Scavenging and cytotoxic activity of pyridine N-oxide was investigated in cultured V3 and CHO cells. Pyridine N-oxide was effective in suppressing the cytotoxic effects induced in these systems both by hydrogen peroxide and adriamycin and preventing the production of chromosomal aberrations by these compounds. On the other hand superoxide dismutase inhibited the cytotoxic activity of pyridine N-oxide.
AuthorsE Anuszewska, J Koziorowska, M Wójtowicz
JournalActa poloniae pharmaceutica (Acta Pol Pharm) Vol. 51 Issue 3 Pg. 223-6 ( 1994) ISSN: 0001-6837 [Print] Poland
PMID7872015 (Publication Type: Journal Article)
Chemical References
  • Pyridines
  • Doxorubicin
  • pyridine N-oxide
  • Hydrogen Peroxide
Topics
  • Animals
  • CHO Cells
  • Cell Survival (drug effects)
  • Cells, Cultured
  • Chlorocebus aethiops
  • Chromosome Aberrations
  • Cricetinae
  • Doxorubicin (toxicity)
  • Hydrogen Peroxide (toxicity)
  • Pyridines (pharmacology)

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