| Abstract | We report a case of Felty's syndrome in which neutropenia was corrected by a short-term treatment with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, 5 micrograms/kg/day s.c. for 14 days). Absolute neutrophil counts rose from 0.1 to 2.2 x 10(9)/l and remained > 1.0 x 10(9)/l 8 weeks after discontinuation of the GM-CSF therapy. A flare-up of arthritis and a decrease in platelet counts were observed. |
| Authors | J Pereira, E D Velloso, H A Loterio, I M Laurindo, D A Chamone
(Affiliation: Fundação Pró-Sangue/Hemocentro de São Paulo, Brazil.)
|
| Journal | Acta haematologica
(Acta Haematol)
Vol. 92
Issue 3
Pg. 154-6
( 1994)
ISSN: 0001-5792 SWITZERLAND |
| PMID | 7871957
(Publication Type: Case Reports, Journal Article, Review)
|
| Chemical References |
- Recombinant Proteins
- Granulocyte-Macrophage Colony-Stimulating Factor
|
| Topics |
- Adult
- Eosinophils
(drug effects)
- Felty's Syndrome
(blood, complications, drug therapy)
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
(administration & dosage)
- Humans
- Leukocyte Count
(drug effects)
- Neutropenia
(blood, drug therapy, etiology)
- Neutrophils
(drug effects)
- Recombinant Proteins
(administration & dosage)
- Remission Induction
- Time Factors
|
