Abstract |
The effects of riboflavin and its derivatives such as FAD, FMN and lumichrome on the levels of high energy phosphate compounds ( ATP and creatine phosphate) and intracellular pH in ischemic reperfused rat hearts were investigated using a Langendorff perfusion technique. 31P-NMR study showed a decrease in the levels of high energy phosphate compounds and pH values in myocardium after 30 min global ischemia and a slight recovery of these levels after a 30 min reperfusion following ischemia. However, in all the hearts perfused with riboflavin and its derivatives during ischemia-reperfusion, a marked recovery of high energy phosphate compounds and pH values were observed. In addition, the cardiac mitochondrial respiratory function was protected from ischemia-reperfusion injury. These results suggest that riboflavin, FAD, FMN, and lumichrome have a protective effect against ischemia-reperfusion injury to rat myocardium in vitro. It is assumed that these substances exert their effect directly in the extracellular space.
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Authors | M Kotegawa, M Sugiyama, N Haramaki |
Journal | Biochemistry and molecular biology international
(Biochem Mol Biol Int)
Vol. 34
Issue 4
Pg. 685-91
(Oct 1994)
ISSN: 1039-9712 [Print] England |
PMID | 7866293
(Publication Type: Journal Article)
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Chemical References |
- Flavins
- Phosphocreatine
- 7,8-dimethylalloxazine
- Flavin-Adenine Dinucleotide
- Flavin Mononucleotide
- Adenosine Triphosphate
- Riboflavin
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Topics |
- Adenosine Triphosphate
(metabolism)
- Animals
- Flavin Mononucleotide
(therapeutic use)
- Flavin-Adenine Dinucleotide
(therapeutic use)
- Flavins
(therapeutic use)
- Hydrogen-Ion Concentration
- Male
- Myocardial Ischemia
(metabolism)
- Myocardial Reperfusion Injury
(prevention & control)
- Myocardium
(metabolism)
- Phosphocreatine
(metabolism)
- Rats
- Rats, Wistar
- Riboflavin
(therapeutic use)
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