Effect of dizocilpine (MK-801) on the catalepsy induced by delta 9-tetrahydrocannabinol in mice.

Abstract

Mice treated with delta 9-tetrahydrocannabinol (THC; 5 and 10 mg/kg i.v.) showed the catalepsy in high bar test, and median descent latencies of catalepsy were about 150 sec. Dizocilpine (MK-801, 0.05 and 0.1 mg/kg), non-competitive N-methyl-D-aspartate (NMDA) antagonist, significantly attenuated THC-induced catalepsy. Furthermore, the anticataleptic effect of MK-801 on THC-induced catalepsy was blocked by acetylcholine agonist oxotremorine (0.005 mg/kg) and dopamine antagonist haloperidol (0.01 mg/kg), but not by NMDA. Oxotremorine, haloperidol, and NMDA themselves did not affect THC-induced catalepsy at the doses used. These results suggest that the anticataleptic effect of MK-801 on THC-induced catalepsy may be developed through dopaminergic and acetylcholinergic neuronal systems.

• Authors: H Kinoshita, T Hasegawa, Y Katsumata, T Kameyama, I Yamamoto, T Nabeshima
• Journal: Journal of neural transmission. General section (J Neural Transm Gen Sect) Vol. 95 Issue 2 Pg. 137-43 ( 1994) Austria
• PMID: 7865168 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, N-Methyl-D-Aspartate
• Oxotremorine
• Dizocilpine Maleate
• Dronabinol
• Haloperidol
• Acetylcholine
• Dopamine

Topics

• Acetylcholine (physiology)
• Animals
• Catalepsy (chemically induced, drug therapy)
• Disease Models, Animal
• Dizocilpine Maleate (antagonists & inhibitors, therapeutic use)
• Dopamine (physiology)
• Dronabinol (toxicity)
• Haloperidol (pharmacology)
• Male
• Mice
• Oxotremorine (pharmacology)
• Parkinson Disease
• Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors, physiology)