[The Extencillin treatment of patients with early forms of syphilis].

Abstract

Outpatient treatment of syphilis was given to 250 patients. All of them received extencilline (benzathine penicillin G) in intramuscular injections. One injection of the drug (2400000 U) was administered for primary seronegative syphilis (15 cases) and for prevention (65 subjects). Two injections with 7-day interval were carried out in the dose 2400000 U for primary seropositive (58 cases), secondary early (14 cases) and recurrent syphilis (36 cases). Patients with secondary recurrent syphilis whose body mass exceeded 85 kg (55 cases) and subjects with latent disease (72 cases) received 3 injections in 7-day intervals. Extencilline proved a potent antisyphilis tool able to rapidly eliminate clinical symptoms of the disease and to promote making serological reactions negative. Extencilline activity is superior to that of bicillin and water-soluble penicillin. Treponema pallidum escape from syphilid surface within 7 treatment hours, on the average. Extencilline is worthy of being used among most effective drugs in outpatient treatment of early syphilis.

• Authors: A L Mashkilleĭson, S A Kutin, V V Kuznetsov
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 66 Issue 10 Pg. 70-3 ( 1994) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Lechenie bol'nykh s rannimi formami sifilisa ékstentsillinom.
• PMID: 7863456 (Publication Type: Journal Article)

Chemical References

• Delayed-Action Preparations
• Penicillin G Benzathine

Topics

• Adolescent
• Adult
• Contraindications
• Delayed-Action Preparations
• Drug Evaluation
• Female
• Humans
• Injections, Intramuscular
• Male
• Middle Aged
• Penicillin G Benzathine (administration & dosage, therapeutic use)
• Recurrence
• Remission Induction
• Syphilis (diagnosis, drug therapy)
• Syphilis Serodiagnosis
• Time Factors