[Acute non-allergic reaction after administration of penicillin as a factor in the occurrence of neurotic symptoms].

Abstract

The effect of a acute non-allergic reaction occurring after injection of procaine penicillin on the occurrence of different neurotic symptoms is a subject of the paper. 31 clinical cases, in which during the penicillin treatment the said reaction took place, were analysed. It has been found that the most often found consequence of that treatment is conversive neurosis, and subsequently the hypochondriac syndrome. On an average an acute non-allergic reaction occurred after the sixth injection. In 94% of the patients the neurotic symptoms appeared immediately after the described reaction. A positive correlation between the patient's age and an intensity of the converse symptoms was found. The Hoigne'a syndrome was a strong mental trauma, and was treated as an allergic shock for all of the patients. The patients were afraid of the next injection and they all refused to give permission for the continuation of such treatment. Neurotic syndromes related to Hoigne's syndrome turned out to be prolonged with a tendency for relapses, and low susceptibility to different methods of treatment. The mechanism of non-allergic acute reaction after procaine penicillin and ways of its prevention are also discussed.

• Authors: P Magiera, L Trojanowski, L Leszczyński
• Journal: Psychiatria polska (Psychiatr Pol) 1994 Nov-Dec Vol. 28 Issue 6 Pg. 677-85 ISSN: 0033-2674 [Print] Poland
• Vernacular Title: Ostra niealergiczna reakcja po penicylinie jako czynnik wyzwalajacy zespoły nerwicowe.
• PMID: 7862754 (Publication Type: English Abstract, Journal Article)

Chemical References

• Penicillins

Topics

• Adult
• Age Factors
• Drug Hypersensitivity
• Female
• Humans
• Male
• Middle Aged
• Neurotic Disorders (etiology, psychology)
• Penicillins (adverse effects)