CD3-negative lymphoproliferative disease of granular lymphocytes in a girl with an unusual pattern of anti-Epstein-Barr virus antibodies.

Abstract

UNLABELLED:

We describe an 11-year-old girl who initially had mild hepatosplenomegaly and then presented with abnormal expansion of CD3-negative granular lymphocytes in peripheral blood and Epstein-Barr virus (EBV) genome in the DNA obtained from the peripheral blood mononuclear cells (PBMNC). After approximately 3 years, she developed oedema, ascites, marked hepatosplenomegaly, and pancytopenia, and showed both a profile of anti-EBV antibodies of reactivated infection and a high titre of anti-cytomegalovirus antibody. Although she was treated with antibiotics, ganciclovir, and prednisolone, she died of hepatic failure.

CONCLUSION:

Careful clinical observation, periodic examination of anti-EBV antibodies, and the analysis of EBV genome from PBMNC are needed in young patients with CD3-negative lymphoproliferative disease of granular lymphocytes.

• Authors: Y Fukunaga, T Asano, J Takehana, K Ambo, K Matsuoka, M Yamamoto
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 153 Issue 12 Pg. 894-7 (Dec 1994) ISSN: 0340-6199 [Print] Germany
• PMID: 7859792 (Publication Type: Case Reports, Journal Article)

Chemical References

• CD3 Complex

Topics

• CD3 Complex (immunology)
• Child
• Fatal Outcome
• Female
• Granulocytes (immunology)
• Hepatomegaly (etiology)
• Herpesvirus 4, Human (immunology)
• Humans
• Lymphoproliferative Disorders (complications, immunology)
• Splenomegaly (etiology)