Artificial endocrine pancreas and optimal blood glucose regulation in diabetic patients--from bedside-type to wearable-type.

Abstract

The artificial endocrine pancreas is a feedback control system regulating insulin delivery on a minute-by-minute basis according to the measured blood glucose levels. The bedside-type artificial endocrine pancreas has been proven to be useful not only as a therapeutic tool for diabetes mellitus but also as an elegant research tool for investigating the pathophysiology of the disease. With significant advances in the development of a subcutaneous tissue glucose monitoring system, the wearable-type artificial endocrine pancreas has been applied to diabetic patients. With this system, perfect glycemic control can be obtained for longer periods in ambulatory diabetic patients. The trend in the development of the artificial endocrine pancreas is now directed to implantable devices. Much efforts have been conducted to realize these devices.

• Authors: M Shichiri, H Kishikawa, M Sakakida, K Kajiwara, Y Hashiguchi, K Nishida, T Uemura, Y Konno, K Ichinose
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 24 Suppl Pg. S251-9 (Oct 1994) ISSN: 0168-8227 [Print] Ireland
• PMID: 7859615 (Publication Type: Journal Article, Review)

Chemical References

• Blood Glucose
• Insulin

Topics

• Blood Glucose (analysis)
• Blood Glucose Self-Monitoring
• Diabetes Mellitus (blood, drug therapy, epidemiology)
• Humans
• Infusion Pumps, Implantable
• Insulin (administration & dosage, therapeutic use)
• Insulin Infusion Systems (standards, trends)
• Japan (epidemiology)