Platelet adenylate cyclase activity in Israeli victims of Iraqi Scud missile attacks with post-traumatic stress disorder.

Abstract

Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-stimulated, PGE1-stimulated or forskolin-stimulated activity between controls and PTSD subjects. Epinephrine inhibition of forskolin-stimulated activity, an effect mediated by alpha 2 adrenergic receptors, was slightly but not significantly increased in the PTSD patients compared to the controls, while 5-HT induced inhibition, an effect mediated by putative 5-HT1a-like receptors, was unchanged. The relationship of these activities to measures of anxiety and depression in these patients is discussed.

• Authors: R Weizmann, E Gur, N Laor, A Reiss, U Muller, A Yoresh, B Lerer, M E Newman
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 114 Issue 3 Pg. 509-12 (Apr 1994) ISSN: 0033-3158 [Print] Germany
• PMID: 7855210 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Colforsin
• Sodium Fluoride
• Adenylyl Cyclases
• Epinephrine

Topics

• Adenylyl Cyclases (blood)
• Adult
• Aged
• Blood Platelets (enzymology)
• Cell Membrane (enzymology)
• Colforsin (antagonists & inhibitors, pharmacology)
• Epinephrine (pharmacology)
• Female
• Humans
• Iraq
• Israel
• Male
• Middle Aged
• Psychiatric Status Rating Scales
• Sodium Fluoride (pharmacology)
• Stimulation, Chemical
• Stress Disorders, Post-Traumatic (blood, enzymology)
• Warfare