Abnormal response to minor histocompatibility antigens in Obese strain chickens.

Abstract

Obese strain chickens, which spontaneously develop autoimmune thyroiditis, were tested for their ability to tolerate skin allografts. Several procedures known to prolong graft survival in normal strains were employed. These included the use of skin matched at the major histocompatibility locus, grafting on the day of hatching, thymectomy, and x-irradiation. A dramatic difference between the Obese and the normal Cornell strain (the strain from which Obese was derived) was detected when both were thymectomized and grafted at hatching. Under these conditions eight of 13 normal but only one of 16 Obese strain birds retained their grafts for 50 days. This suggests the presence of an abnormal thymus or thymus-derived suppressor T cells in Obese strain chickens.

• Authors: M Jakobisiak, R S Sundick, L D Bacon, N R Rose
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 73 Issue 8 Pg. 2877-80 (Aug 1976) ISSN: 0027-8424 [Print] United States
• PMID: 785474 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Autoantibodies
• Histocompatibility Antigens

Topics

• Age Factors
• Animals
• Autoantibodies (analysis)
• Autoimmune Diseases (genetics)
• Chickens (immunology)
• Graft Rejection (radiation effects)
• Histocompatibility Antigens
• Radiation Effects
• Skin Transplantation
• Thymectomy
• Thymus Gland (immunology)
• Thyroiditis, Autoimmune (immunology)
• Transplantation, Homologous
• X-Rays