Augmentation of host resistance against bacterial infection by treatment with leustroducsin B, a new CSF inducer.

Abstract

We tested the in vivo activity of leustroducsin B (LSN B), a new colony-stimulating factor (CSF) inducer isolated from the culture broth of Streptomyces platensis, with mice infected with Escherichia coli. Treatment with LSN B augmented the host resistance to lethal infection of E. coli at doses between 0.1 mg/kg and 1 mg/kg. Serum interleukin-6 (IL-6) levels were found to increase after this treatment, and superoxide anion generation of neutrophils was enhanced in vivo, suggesting that LSN B augmented the host resistance at least in part by inducing IL-6, which subsequently enhanced the bactericidal activity of the neutrophils.

• Authors: T Kohama, T Katayama, M Inukai, H Maeda, A Shiraishi
• Journal: Microbiology and immunology (Microbiol Immunol) Vol. 38 Issue 9 Pg. 741-5 ( 1994) ISSN: 0385-5600 [Print] Australia
• PMID: 7854215 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Colony-Stimulating Factors
• Interleukin-6
• Lactones
• Organophosphorus Compounds
• Pyrones
• Superoxides
• leustroducsin B

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Colony-Stimulating Factors (pharmacology)
• Enzyme-Linked Immunosorbent Assay
• Escherichia coli Infections (blood, immunology, prevention & control)
• Immunity (drug effects)
• Interleukin-6 (blood)
• Lactones (pharmacology)
• Male
• Mice
• Mice, Inbred ICR
• Neutrophils (drug effects, physiology)
• Organophosphorus Compounds (pharmacology)
• Pyrones
• Superoxides (metabolism)